Key topics covered in this interview:
• Dr. Mariela Glandt’s journey from traditionally trained endocrinologist to low-carb “rebel” after discovering the therapeutic carbohydrate reduction literature
• How opening her own private practice in Israel gave her the freedom to test low-carb and ketogenic protocols without institutional resistance
• The evolution from a wealthy Tel Aviv diabetes clinic to Ona Health’s mission of bringing diabetes reversal care to underserved Medicaid populations in the U.S.
• Why she believes type 2 diabetes does not have to be accepted as genetic destiny — and how food can reverse the direction of the disease process
• The difference between controlling diabetes with medication and truly changing the trajectory through nutrition, ketosis, coaching, and physician-led care
• Why Dr. Glandt prefers going “all in” with patients instead of easing in slowly, so they can quickly experience reduced hunger, cravings, and blood sugar improvement
• The role of family and spousal support, and why she tries to involve partners early so the household doesn’t become a daily source of food conflict
• The challenge of treating underserved patients who are not actively looking for low-carb care, but are referred by doctors and surprised by the approach
• GLP-1 medications as a useful tool, not the full solution — and why she sees the diet as essential for diabetes reversal, satiety, muscle preservation, and long-term success
• Her observation that GLP-1s sometimes “kick in” only after patients start a low-carb diet, suggesting the diet may increase GLP-1 responsiveness
• The most important early warning signs of insulin resistance: belly fat, high blood pressure, high triglycerides, low HDL, elevated A1C, and fasting insulin
• Why fasting insulin is one of the most overlooked but powerful tests — and how a high fasting insulin means the body is still in fat-storage mode even when not eating
• The teenage obesity crisis, why Dr. Glandt focuses first on getting kids off sugar and junk food, and why real food matters even before strict keto is considered
• Her sense of hope and purpose in helping patients move from more medications and decline toward energy, clarity, health, and freedom from diabetes progression